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PXD007048 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCell-specific proteome analyses of human bone marrow upon aging.
DescriptionDiminishing potential to replace damaged tissues is a hallmark for aging of somatic stem cells, but the mechanisms leading to aging remain elusive. We performed a proteome-wide analysis of human hematopoietic stem and progenitor cells (CD34+) along with five other cell types that constitute the bone marrow niche, namely, lymphocytes and precursors; monocytes/macrophages and precursors; granulocytic precursors and erythroid precursors, as well as mesenchymal stem/stromal cells. In total, we analyzed 270 samples from 59 human subjects. The data represents a valuable resource for further in-depth mechanistic analyses, and for validation of knowledge gained from animal models.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMarco L. Hennrich
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-07-14 04:11:15ID requested
12018-07-31 00:48:16announced
22019-02-12 08:32:48announcedUpdated publication reference for PubMed record(s): 30275468.
Publication List
Hennrich ML, Romanov N, Horn P, Jaeger S, Eckstein V, Steeples V, Ye F, Ding X, Poisa-Beiro L, Lai MC, Lang B, Boultwood J, Luft T, Zaugg JB, Pellagatti A, Bork P, Aloy P, Gavin AC, Ho AD, Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline. Nat Commun, 9(1):4004(2018) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: aging, hematopoietic stem cells, mesenchymal stem/stromal cells, human, TMT, label-free quantification
Contact List
Anne-Claude Gavin
contact affiliationEMBL Heidelberg
contact emailgavin@embl.de
lab head
Marco L. Hennrich
contact affiliationEMBL Heidelberg
contact emailmarco.hennrich@embl.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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