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PXD006867 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleModulation of intestinal proteome of juvenile common carp (Cyprinus carpio L.) after dietary exposure to ZnO nanoparticles
DescriptionZnO nanoparticles (NPs) are widely used in industrial and consumer products. Thus, understanding their interaction with biological systems is the key for their safe application. The aim of present study was to evaluate the toxicological effects on the intestine of common carp, Cyprinus carpio, after dietary exposure to ZnO NPs. To assess the toxicity of ZnO NPs and of their toxic mechanism to gastrointestinal tract, we applied label free protein quantification on carp intestine considering the fact that fish are on the top of food chain in aquatic ecosystems. Even though carp and zebrafish do not have five intestinal segments like mammals (Brugman, 2016), previous studies have revealed that intestinal anatomy and architecture in cyprinid teleost fish is closely related to mammals with functional homology (Curry, 1939). Therefore, the findings can also provide beneficial information to understand the mechanisms underlying NPs toxicity in mammals.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLatifeh Chupani
SpeciesList scientific name: Cyprinus carpio Linnaeus; NCBI TaxID: 7962;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-07-05 07:38:56ID requested
12017-09-25 01:53:27announced
Publication List
Chupani L, Niksirat H, L, ü, nsmann V, Haange SB, von Bergen M, Jehmlich N, Zuskova E, Insight into the modulation of intestinal proteome of juvenile common carp (Cyprinus carpio L.) after dietary exposure to ZnO nanoparticles. Sci Total Environ, 613-614():62-71(2018) [pubmed]
Keyword List
curator keyword: Technical, Biomedical
submitter keyword: Apoptosis
common carp
ZnO nanoparticles
Contact List
Dr. Nico Jehmlich
contact affiliationHelmholtz-Centre for Environmental Research - UFZ, Department of Molecular Systems Biology, Leipzig, Germany
contact emailnico.jehmlich@ufz.de
lab head
Latifeh Chupani
contact affiliationUniversity of South Bohemia in České Budějovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Centre of Aquaculture and Biodiversity of Hydrocenoses, Research Institute of Fish Culture and Hydrobiology, Vodňany, Czech Republic
contact emaillchupani@frov.jcu.cz
dataset submitter
Full Dataset Link List
Dataset FTP location
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