PXD006512

PXD006512 is an original dataset announced via ProteomeXchange.

Title	Proteome Landscape of Early Stage Hepatocellular Carcinoma Identifies Proteomic Subtypes and New Therapeutic Targets
Description	Hepatocellular carcinoma (HCC) accounts for approximately 90% of primary liver cancers, the second leading cause of cancer mortality worldwide. Although HCC surgical treatment may be curative in the early stages, its five-year overall survival is only 50-70%. Advances in proteomic technologies have expanded the breadth and depth of cancer proteome characterization. Here, we present the largest characterization effort on proteomic profiling of 222 tumor and paired non-tumor tissues in clinically early HCC (Barcelona Clinic Liver Cancer (BCLC) stage 0 and A). Quantitative proteomic data identified three more-refined subtypes in the early- stage cohort of HCC (termed S-I, S-II and S-III) with different clinical outcomes. S-I retained hepatic detoxification and metabolic functions with the best prognosis, S-II increased molecular expression related to proliferation, and S-III showed distinct enrichment of tumor metastasis and immune response pathways and the poorest prognosis. The subtype specific signatures targeted by known FDA approved drugs or inhibitors under clinical investigations for HCC provide a novel resource for HCC therapeutic targets. A new mechanism of disrupted cholesterol homeostasis with aberrant accumulation of cholesteryl esters was also highlighted in S-III. Thus, this study represents the first proteomic stratification of early-stage HCC, providing insights into tumor biology and personalized targeted therapy.
HostingRepository	PRIDE
AnnounceDate	2019-05-30
AnnouncementXML	Submission_2019-05-30_08:33:49.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yang Zhao
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2017-05-15 00:26:22	ID requested
1	2019-02-28 03:16:00	announced
2	2019-03-01 06:13:40	announced	Updated publication reference for PubMed record(s): 30814741.
⏵ 3	2019-05-30 08:33:51	announced	Updated publication reference for PubMed record(s): 30814741.

Jiang Y, Sun A, Zhao Y, Ying W, Sun H, Yang X, Xing B, Sun W, Ren L, Hu B, Li C, Zhang L, Qin G, Zhang M, Chen N, Zhang M, Huang Y, Zhou J, Zhao Y, Liu M, Zhu X, Qiu Y, Sun Y, Huang C, Yan M, Wang M, Liu W, Tian F, Xu H, Zhou J, Wu Z, Shi T, Zhu W, Qin J, Xie L, Fan J, Qian X, He F, He F, Qian X, Qin J, Jiang Y, Ying W, Sun W, Zhu Y, Zhu W, Wang Y, Yang D, Liu W, Liu Q, Yang X, Zhen B, Wu Z, Fan J, Sun H, Qian J, Hong T, Shen L, Xing B, Yang P, Shen H, Zhang L, Cheng S, Cai J, Zhao X, Sun Y, Xiao T, Mao Y, Chen X, Wu D, Chen L, Dong J, Deng H, Tan M, Wu Z, Zhao Q, Shen Z, Chen X, Gao Y, Sun W, Wang T, Liu S, Lin L, Zi J, Lou X, Zeng R, Wu Y, Cai S, Jiang B, Chen A, Li Z, Yang F, Chen X, Sun Y, Wang Q, Zhang Y, Wang G, Chen Z, Qin W, Li Z, Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma. Nature, 567(7747):257-261(2019) [pubmed]

ProteomeXchange project tag: Cancer (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

curator keyword: Biomedical

submitter keyword: Human, Liver cancer,Proteomics

Fuchu He
contact affiliation	State Key Laboratory of Proteomics, National Center for Protein Sciences Beijing, 38 Life Science Park Road, Beijing 102206, P.R. China.
contact email	hefc@bmi.ac.cn
lab head
Yang Zhao
contact affiliation	State Key Laboratory of Proteomics, National Center for Protein Sciences Beijing, 38 Life Science Park Road, Beijing 102206, P.R. China.
contact email	CNHPP_Liver@126.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/05/PXD006512

PRIDE project URI

• PRIDE
  1. PXD006512
     1. Label: PRIDE project
     2. Name: Proteome Landscape of Early Stage Hepatocellular Carcinoma Identifies Proteomic Subtypes and New Therapeutic Targets