Updated publication reference for PubMed record(s): 30112417, 32174813. In our study, we apply isobaric tag for relative and absolute quantitation (iTRAQ) followed by multidimensional liquid chromatography and tandem MS analysis(LC-MS-MS). The iTRAQ labeling were performed according to the manufacturer's protocol (Applied Biosystems).8 groups of samples were labeled and repeatedly identified in one technical replicates.