This submission contains the mass spectrometry files for the manuscript by Lambert, Picaud et al. that describes the characterization of interactome changes induced by JQ1 on the BET proteins. More precisely, files used in the SAINT express task 2096 are in this dataset. The pulldown experiments using recombinant BRD4 domains acquired on a Velos Orbitrap Elite mass spectrometer are found here. See the README file within "Materials and Methods" and the accompanying files for a complete description of MS data generated.