PXD006279

PXD006279 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane
Description	Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane’s targets and identify over 500 targets along with their relative affinities. These targets provide a new set of mediators for sulforaphane’s bioactivity, and aid understanding of its complex mode of action.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:01:42.876.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thomas Lanyon-Hogg
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	6x(13)C labeled residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2017-04-10 03:57:38	ID requested
1	2017-05-23 23:37:58	announced
⏵ 2	2024-10-22 04:01:50	announced	2024-10-22: Updated project metadata.

Publication List

10.1039/c6cc08797c;
Clulow JA, Storck EM, Lanyon-Hogg T, Kalesh KA, Jones LH, Tate EW, Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb), 53(37):5182-5185(2017) [pubmed]

10.1039/c6cc08797c;

Clulow JA, Storck EM, Lanyon-Hogg T, Kalesh KA, Jones LH, Tate EW, Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb), 53(37):5182-5185(2017) [pubmed]

Keyword List

curator keyword: Biomedical
submitter keyword: Sulforaphane
cancer
chemical proteomics

curator keyword: Biomedical

submitter keyword: Sulforaphane

cancer

chemical proteomics

Contact List

Edward Tate
contact affiliation	Department of Chemistry, Imperial College London, UK
contact email	e.tate@imperial.ac.uk
lab head
Thomas Lanyon-Hogg
contact affiliation	Imperial College London
contact email	t.lanyon-hogg@imperial.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/05/PXD006279
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/05/PXD006279

PRIDE project URI

Repository Record List

[ + ]