Updated project metadata. Control subjects and type 2 diabetic patients were given deuterium-labeled (heavy) water for a seven-day period and their plasma serum proteins were analyzed by high-resolution mass spectrometry. Using an in-house-developed software, fractional synthesis rates were calculated for proteins of interest. These data can be used for qualitative, quantitative, and kinetics study of human serum proteins under healthy and type 2 diabetes conditions.