PXD004198-1

PXD004198 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of extracellular vesicles derived from Merkel cell carcinoma cell lines
Description	Exosomes constitute an evolutionary conserved mechanism of intercellular signaling. Their importance are gaining increasing such as prognostic and diagnostic markers, and potential therapeutic tool. Merkel cell carcinoma (MCC) is an aggressive form of skin cancer with a poor prognosis. There are not available an effective systemic treatment for this type of cancer, and exosome-based therapy was proposed. We identified with high confident 164 exosome-derived proteins that were common for all four cell lines, which were annotated in ExoCarta and Vesiclepedia databases. This list includes proteins implicated in motility, metastasis and tumor progression.
HostingRepository	PRIDE
AnnounceDate	2016-08-08
AnnouncementXML	Submission_2016-08-08_09:10:27.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jack-Ansgar Bruun
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-05-23 01:57:06	ID requested
⏵ 1	2016-08-08 09:10:28	announced
2	2024-10-22 04:29:41	announced	2024-10-22: Updated project metadata.

Konstantinell A, Bruun JA, Olsen R, Aspar A, Š, kalko-Basnet N, Sveinbj, ø, rnsson B, Moens U, Secretomic analysis of extracellular vesicles originating from polyomavirus-negative and polyomavirus-positive Merkel cell carcinoma cell lines. Proteomics, 16(19):2587-2591(2016) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: proteomics, exosome, polyomavirus, Merkel cell carcinoma, cancer

Ugo Moens
contact affiliation	Department of Medical Biology, University of Tromsø, Faculty of Health Sciences NO-9037 Tromsø, Norway (group leader)
contact email	ugo.moens@uit.no
lab head
Jack-Ansgar Bruun
contact affiliation	University of Tromsø
contact email	jack-ansgar.bruun@uit.no
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/08/PXD004198

PRIDE project URI

• PRIDE
  1. PXD004198
     1. Label: PRIDE project
     2. Name: Proteomic analysis of extracellular vesicles derived from Merkel cell carcinoma cell lines