Updated project metadata. In 2010, Ascaris caused 819 million infections worldwide. The impact on children is particularly severe, causing growth retardation and detrimental effects on cognitive development. Transmission is linked to unhygienic defecation habits, making ascariasis a disease of poverty. The WHO recognises it as one of the world's 17 neglected tropical diseases. Ascariasis is also an important parasite of pigs with economic implications including liver condemnation. Intriguingly some people (and pigs) are very heavily infected with Ascaris whereas others are not and this research aims to understand the factors that give rise to this difference and ultimately resistance to Ascaris itself. In our study we performed label free quantitative proteomics on livers of day four post infection C57BL/6J and CBA/Ca mice with and without Ascaris infection to identify proteins changes potentially linked to both resistance and susceptibility amongst the two strains, respectively. In addition tio major intrinsic differences between the two strains signatures of a differential immune response and direct modulation of host processes by the nematode were resolved.