Updated project metadata. The transcriptome, proteome and metabolome of 16 S.cerevisiae backgrounds, combinatorially perturbed in HIS3, LEU2, URA3 and MET15strains are compared. The project was jointly supervised by Kathryn Lilley and Markus Ralser. Transcriptome data has been deposited at ArrayExpress under accession <a href="http://www.ebi.ac.uk/microarray-as/aer/result?queryFor=Experiment&eAccession=E-MTAB-3991">E-MTAB-3991</a>. Metabolome data has been deposited at Metabolights with accession number <a href="http://www.ebi.ac.uk/metabolights/MTBLS168">MTBLS168</a>.