PXD080765 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Urinary Proteome Profiling by Several Methods Identifies Titin as the Most-Differentiating Noninvasive Urinary Biomarker of Disease Severity in Becker Muscular Dystrophy |
| Description | Becker’s muscular dystrophy (BMD) is a milder, yet clinically heterogeneous, dystrophinopathy compared to Duchenne muscular dystrophy (DMD). It arises from in-frame mutations in the dystrophin gene, producing truncated but partially functional dystrophins, resulting in highly variable disease severity that can range from severe impairment to asymptomatic cases. In this study, we performed urinary proteome profiling to identify potential non-invasive protein biomarkers for assessing muscle injury in individuals with BMD, encompassing a broad spectrum of disease severities and ages. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-10-05 |
| AnnouncementXML | Submission_2026-10-05_02:14:01.252.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD080765 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Kimchi K. Le |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-07-08 17:29:21 | ID requested | |
| ⏵ 1 | 2026-10-05 02:14:02 | announced | |
Publication List
| 10.6019/PXD080765; |
| 10.3390/proteomes14030043; |
| Le KK, Canessa EH, Stahura CM, Mayers J, Edwards KA, Barbieri M, Hoffman EP, Hathout Y, Urinary Proteome Profiling by Several Methods Identifies Titin as the Most-Differentiating Noninvasive Urinary Biomarker of Disease Severity in Becker Muscular Dystrophy. Proteomes, 14(3):(2026) [pubmed] |
Keyword List
| submitter keyword: Becker Muscular Dystrophy |
| biomarkers |
| n-terminal titin |
| urine samples |
| proteomics |
| non-invasive |
Contact List
| Yetrib Hathout |
|---|
| contact affiliation | Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Binghamton University – SUNY, Johnson City, New York 13790, United States |
| contact email | yhathout@binghamton.edu |
| lab head | |
| Kimchi K. Le |
|---|
| contact affiliation | Binghamton University |
| contact email | kle5@binghamton.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/10/PXD080765 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD080765
- Label: PRIDE project
- Name: Urinary Proteome Profiling by Several Methods Identifies Titin as the Most-Differentiating Noninvasive Urinary Biomarker of Disease Severity in Becker Muscular Dystrophy
