PXD079577

PXD079577 is an original dataset announced via ProteomeXchange.

Title	A STRUBBELIG-NHL3 cell surface receptor complex mediates the response to cellulose deficiency in Arabidopsis
Description	Plant cells are enclosed by a semi-rigid cell wall with a complex biochemical composition and architecture. The poorly understood remodeling of the cell wall is crucial for controlling growth and development, as well as for regulating abiotic and biotic stress responses. Cell wall remodeling upon disruption of cell wall integrity by inhibition of cellulose biosynthesis (CBI) depends on the receptor kinase STRUBBELIG (SUB) and its binding partner QUIRKY (QKY). Here, we identify NON-RACE SPECIFIC DISEASE RESISTANCE/HIN1 HAIRPIN-INDUCED-LIKE protein 2 (NHL2) and NHL3 as additional factors involved in the SUB-dependent CBI response. Collectively, our data indicate that NHL3 maintains SUB at the plasma membrane by physically interacting with SUB. SUB signaling is attenuated by receptor-mediated endocytosis initiated by release of first the SUB/NHL3 and later the SUB/QKY interaction. Our results further suggest a diverse set of biochemically and functionally distinct SUB complexes involved in regulating cell wall integrity and development.
HostingRepository	PRIDE
AnnounceDate	2026-06-11
AnnouncementXML	Submission_2026-06-11_04:24:08.261.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Julia Mergner
SpeciesList	scientific name: Arabidopsis thaliana (Mouse-ear cress); NCBI TaxID: NEWT:3702;
ModificationList	phosphorylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2026-06-11 04:12:43	ID requested
⏵ 1	2026-06-11 04:24:08	announced

Dataset with its publication pending

submitter keyword: cell wall signaling, receptor kinase,cellulose, QUIRKY

Bernhard Kuster
contact affiliation	Chair of Proteomics and Bioanalytics, Technical University of Munich, Germany
contact email	kuster@tum.de
lab head
Julia Mergner
contact affiliation	Chair of Proteomics and Bioanalytics, TU Munich
contact email	julia.mergner@tum.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD079577
     1. Label: PRIDE project
     2. Name: A STRUBBELIG-NHL3 cell surface receptor complex mediates the response to cellulose deficiency in Arabidopsis