⮝ Full datasets listing
PXD074827
PXD074827 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | PFKM promotes the survival of GBM cells under glucose deprivation |
| Description | PFKM is the second rate-limiting step of glycolysis, catalyzing the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate. Here we show, using an orthotopic xenograft glioma mouse model, that PFKM is deubiquitinated and translocated into nucleus upon glucose deficiency, thereby activating fatty acid oxidation (FAO), which sustains tumor cell survival and ultimately promotes GBM development. |
| HostingRepository | iProX |
| AnnounceDate | 2026-02-15 |
| AnnouncementXML | Submission_2026-05-06_18:27:10.134.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Siyang Wu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-02-24 18:25:52 | ID requested | |
| ⏵ 1 | 2026-05-06 18:27:10 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: PFKM, Cancer Metabolism |
Contact List
| Weiwei Yang | |
|---|---|
| contact affiliation | Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences |
| contact email | wyang@sibcb.ac.cn |
| lab head | |
| Siyang Wu | |
| contact affiliation | Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences |
| contact email | wusiyang0815@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
