PXD073707

PXD073707 is an original dataset announced via ProteomeXchange.

Title	Proteomics analysis of exosomes derived from human umbilical cord mesenchymal stem cells
Description	Mesenchymal stem cell-derived exosomes (MSC-Exos), noted for their minimal immunogenicity and robust immunomodulatory potential, have emerged as key regulators of immune cell fate. Nevertheless, a comprehensive understanding of their global impact on human NK cell proliferation and effector function remains elusive. In this study, we employed a standardized ex vivo expansion and exosome-priming system to systematically evaluate the regulatory effects of MSC-Exos on peripheral blood-derived NK cells via flow cytometry, cytotoxicity assays, single-cell transcriptomics, and proteomic profiling. Proteomic profiling identified an enrichment of FcγR-related signaling components within MSC-Exos, suggesting a potential role in enhancing antibody-dependent cellular cytotoxicity (ADCC).Collectively, our findings demonstrate that MSC-Exos bolster NK cell expansion and effector maturation through coordinated immuno-metabolic reprogramming, offering a strategic approach to enhancing the therapeutic efficacy of NK cell-based immunotherapies.
HostingRepository	PRIDE
AnnounceDate	2026-04-16
AnnouncementXML	Submission_2026-04-15_23:40:32.973.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bu fanyu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF Pro 2

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-28 03:12:09	ID requested
⏵ 1	2026-04-15 23:40:33	announced

Dataset with its publication pending

submitter keyword: None

Xuan Dong
contact affiliation	Center for Regeneration and Aging,BGI-haangzhou
contact email	dongxuan@genomics.cna
lab head
Bu fanyu
contact affiliation	15105131523
contact email	bufanyu@genomics.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD073707
     1. Label: PRIDE project
     2. Name: Proteomics analysis of exosomes derived from human umbilical cord mesenchymal stem cells