⮝ Full datasets listing
PXD073308
PXD073308 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The Desmoglein 2 interactome in primary neonatal cardiomyocytes |
| Description | Mechanical coupling and chemical communication between cardiomyocytes are facilitated through a specialized adhesive structure known as the intercalated disc (ICD). The ICD is essential for heart organization and contraction. Yet, the network of adhesion, adaptor, and signaling proteins that form the ICD remains poorly defined. Here, we combined proximity labeling and quantitative mass spectrometry to identify proteins associated with the desmosomal cadherin, Desmoglein 2 (DSG2), in cultured neonatal cardiomyocytes. We identified over 300 proteins in the DSG2 interactome; half of which are shared with the N-cadherin (CDH2) interactome in cardiomyocytes. Proteins unique to DSG2 include the gap junction protein connexin 43 and the plakin family of cytolinker proteins. Comparison of the cardiomyocyte DSG2 interactome with the interactomes of desmosomal proteins from epithelia revealed only a small number of shared proteins. In cardiomyocytes, plakoglobin (JUP) and plakophilin 2 (PKP2) were the most abundant shared proteins between the DSG2 and CDH2 interactomes. PKP2 is a dynamic protein whose membrane recruitment in cardiomyocytes is tension-dependent. Our analysis of the DSG2 interactome provides a critical new dimension to the proteomic atlas of the essential molecular complexes required for cardiomyocyte adhesion. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-01-21 |
| AnnouncementXML | Submission_2026-01-21_18:22:53.240.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xuemei Zeng |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | L-methionine sulfoxide |
| Instrument | LTQ Orbitrap Velos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-01-20 18:53:22 | ID requested | |
| ⏵ 1 | 2026-01-21 18:22:53 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Desmoglein 2, interactome, BioID2, DatasetType:Proteomics |
Contact List
| Adam V. Kwiatkowski | |
|---|---|
| contact affiliation | University of Pittsburgh |
| contact email | adamkwi@pitt.edu |
| lab head | |
| Xuemei Zeng | |
| contact affiliation | University of Pittsburgh |
| contact email | xuzst1@yahoo.com |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v12/MSV000100533/ |
