⮝ Full datasets listing
PXD073001
PXD073001 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | RHOA Controls Oncogenic B-Cell Receptor Signaling in Aggressive Lymphoma |
| Description | Diffuse large B cell lymphoma (DLBCL), divided into activated B-cell-like (ABC) and germinal center B-cell-like (GCB), is the most common type of aggressive lymphoma. While many studies have shown treatment response differences based on subtype, recurrently mutated proteins can further alter these responses and may require therapeutic alterations. Mutational effects in DLBCL have recently begun to be investigated, of which one mutated protein, the master cytoskeletal regulator RhoA, is here evaluated. While having been identified in previous studies, a complete investigation into the effects of this protein and its mutations in the context of DLBCL have been lacking. Through use of various methodologies, RhoA was found to play a role in the chronic active BCR signaling and NF-KB survival signal that are characteristic for the ABC DLBCL subtype. Not only was it essential in proximal BCR signaling, but additionally in the formation of the My-T-BCR super-signaling complex. Additionally, the interaction with essential surface membrane signalling proteins, and effects on internalization, emphasize the importance of this protein. Differing point mutations alter the activity of RhoA itself, along with its response to various clinically relevant inhibitors, clustering of IgM on the plasma membrane, and the actin cytoskeleton. The investigation of RhoA and its recurrent mutations are essential for deeper understanding of this malignancy. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-01-13 |
| AnnouncementXML | Submission_2026-01-13_08:20:05.258.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Bj�rn H�upl |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Phospho |
| Instrument | Orbitrap Exploris 480; Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-01-13 02:55:33 | ID requested | |
| ⏵ 1 | 2026-01-13 08:20:05 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: RHOA, Lymphoma, DLBCL, BCR, DatasetType:Proteomics |
Contact List
| Prof. Dr. Thomas Oellerich | |
|---|---|
| contact affiliation | Goethe University Clinic Frankfurt |
| contact email | oellerich@em.uni-frankfurt.de |
| lab head | |
| Bj�rn H�upl | |
| contact affiliation | DKFZ/DKTK |
| contact email | b.haeupl@dkfz-heidelberg.de |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v11/MSV000100447/ |
