⮝ Full datasets listing
PXD070376
PXD070376 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Magnesium modulates the stress response of oral streptococci to environmental and antibiotic challenges by altering cell envelope and nutrient transport pathways |
| Description | Magnesium supplementation increases the tolerance of various Streptococcus species to environmental stressors, specifically osmotic and Zn-excess. In order to understand the mechanism of Mg-dependent stress tolerance, a putative Mg2+-efflux pump gene, hlyX, has been deleted in Streptococcus mutans. The effects of Mg2+ supplementation on wild-type and Delta-hlyX strains regarding growth, stress tolerance, and intracellular metal concentrations were compared to elucidate the role of HlyX in Mg2+ efflux. Proteomic and lipidomic analyses of the wild-type and Delta-hlyX strains in the presence of 25 mM MgCl2 were compared with those grown in unsupplemented media. Proteomic and lipidomic analyses revealed altered levels of amino acid transporters, cell envelope proteins, and an increase in long-chain unsaturated fatty acids. Furthermore, modulating intracellular Mg2+ concentration, either by MgCl2 supplementation or by eliminating HlyX, impacted the efficacy of multiple cell wall-targeting antibiotics. |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-12-11 |
| AnnouncementXML | Submission_2025-12-11_10:25:21.798.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Chunna Guo |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | instrument model |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-11-05 13:13:24 | ID requested | |
| ⏵ 1 | 2025-12-11 10:25:22 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: human, liver, plasma, LC-MSMS, DatasetType:Proteomics |
Contact List
| Surabhi Mishra | |
|---|---|
| contact affiliation | Dept. of Biomedical and Applied Sciences Indiana School of Dentistry |
| contact email | sumishr@iu.edu |
| lab head | |
| Chunna Guo | |
| contact affiliation | Indiana University |
| contact email | cg41@iu.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v11/MSV000099768/ |
