⮝ Full datasets listing
PXD070327
PXD070327 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Shigella flexneri evades septin-mediated cell-autonomous immunity via protein ADP-riboxanation |
| Description | We demonstrate that OspC effectors enable S. flexneri to evade septin cage entrapment. Mechanistically, OspC catalyzes ADP-riboxanation of SEPT9 at Arg561, a critical site essential for stabilizing septin hetero-oligomers. Notably, ADP-riboxanation or mutation of Arg561 impairs septin polymerization and hence the assembly of higher-order structures, including filaments and cage-like structures. Finally, we provide evidence that S. flexneri OspC effectors act synergistically with OspG to antagonize septin cage entrapment via two distinct post-translational modifications. |
| HostingRepository | iProX |
| AnnounceDate | 2025-11-04 |
| AnnouncementXML | Submission_2025-11-04_17:43:15.208.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhiheng Tang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ; LTQ Orbitrap Velos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-11-04 17:42:41 | ID requested | |
| ⏵ 1 | 2025-11-04 17:43:15 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: ADP-ribosylome, IP-MS, SEPT9, OspC, Shigella |
Contact List
| Xiaoyun Liu | |
|---|---|
| contact affiliation | Peking University Health Science Center |
| contact email | xiaoyun.liu@bjmu.edu.cn |
| lab head | |
| Zhiheng Tang | |
| contact affiliation | Peking University Health Science Center |
| contact email | zhihengt@pku.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
