⮝ Full datasets listing
PXD070204
PXD070204 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | DCAF15-mediated EphA2 degradation triggers disruption of the blood-brain barrier during Streptococcus suis meningitis |
| Description | his study reveals that EphA2 protects the blood-brain barrier (BBB) during Streptococcus suis infection by mediating autophagy. The pathogen subverts this defense by using its serine/threonine kinase (STK) to trigger a signaling cascade (SIRT1/DCAF15) that promotes EphA2 ubiquitination and degradation, thereby disrupting the BBB. These findings identify EphA2 as a potential therapeutic target for bacterial meningitis. |
| HostingRepository | iProX |
| AnnounceDate | 2025-10-31 |
| AnnouncementXML | Submission_2025-11-03_00:13:50.007.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hang Yin |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | acetylated residue; phosphorylated residue |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-11-03 00:13:36 | ID requested | |
| ⏵ 1 | 2025-11-03 00:13:50 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: DCAF15 EphA2 |
Contact List
| Rendong Fang | |
|---|---|
| contact affiliation | College of Veterinary Medicine, Southwest University |
| contact email | rdfang@swu.edu.cn |
| lab head | |
| Hang Yin | |
| contact affiliation | College of Veterinary Medicine, Southwest University |
| contact email | yinhang2022@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
