PXD070085

PXD070085 is an original dataset announced via ProteomeXchange.

Title	Proteomics of Prostate Cancer Tissue Small Extracellular Vesicles Reveal Alteration of Metabolism
Description	In this study, we created a method to isolate prostate tissue small EVs, based on our knowledge of the murine prostate cancer model building. Our data suggested that prostate tissue small EVs proteins significantly changed in many metabolism pathways, such as Glycolysis, Biogenesis of amino acids, Carbon metabolism and Pyruvate metabolism. In this study, we are the first to report prostate tissue derived EVs proteins enriched in alterations of cancer metabolism. These differential proteins in PCa tissue EVs reflect metabolic changes in PCa and may provide insights into the development of early diagnostic biomarkers or novel therapeutic strategies.
HostingRepository	iProX
AnnounceDate	2025-10-30
AnnouncementXML	Submission_2025-10-30_01:36:08.562.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lijuan Yu
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-30 01:35:42	ID requested
⏵ 1	2025-10-30 01:36:09	announced

Dataset with its publication pending

submitter keyword: Prostate cancer, tissue EVs, tumor metabolism, Glycolysis

Lijuan Yu
contact affiliation	Sahlgrenska Center for Cancer Research and Wallenberg Centre for Molecular and Translational Medicine, Department of Surgery, Institute of Clinical Sciences, University of Gothenburg
contact email	lijuan.yu@gu.se
lab head
Lijuan Yu
contact affiliation	Sahlgrenska Center for Cancer Research and Wallenberg Centre for Molecular and Translational Medicine, Department of Surgery, Institute of Clinical Sciences, University of Gothenburg
contact email	lijuan.yu@gu.se
dataset submitter

iProX dataset URI