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PXD070066
PXD070066 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic analysis of Rhitymna verruca |
| Description | Rhitymna verruca is a large nocturnal wandering spider and an important natural predator of agricultural and forestry pests, with its venom playing a key role in prey capture. However, systematic studies on the composition of its venom remain scarce. In this study, we performed an integrated analysis of the venom gland and venom samples using high-throughput transcriptome sequencing combined with quantitative proteomics. The transcriptome yielded 43,244 representative unigene sequences, among which 102 toxin-like sequences were identified through functional annotation, encompassing 13 peptide toxin superfamilies and 7 protein toxin families. Proteomic analysis identified 35 venom components, including 14 peptide toxins and 21 functional proteins. The most abundantly expressed toxin families, Superfamily IX and VII, were highly expressed at both transcriptomic and proteomic levels, suggesting central roles in prey paralysis and neuroregulation. Most peptide toxins possessed ICK or Kunitz domains, indicating high structural stability and potential target specificity. In addition, the venom was rich in auxiliary components such as CAP protein superfamily, hyaluronidases, and metalloproteases, which may contribute to toxin synergy, diffusion, and tissue disruption. This study provides the first comprehensive characterization of the venom composition of R. verruca, offering fundamental insights into its functional mechanisms, evolutionary patterns, and potential applications in the development of novel bioactive agents. |
| HostingRepository | iProX |
| AnnounceDate | 2025-10-29 |
| AnnouncementXML | Submission_2025-10-29_20:36:45.171.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhi Li |
| SpeciesList | scientific name: unclassified Sparassidae; NCBI TaxID: 1046829; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-10-29 20:36:25 | ID requested | |
| ⏵ 1 | 2025-10-29 20:36:45 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Rhitymna verruca, Spider venom, Toxins, Proteomics |
Contact List
| Zhi Li | |
|---|---|
| contact affiliation | Dali University |
| contact email | liii_cc@163.com |
| lab head | |
| Zhi Li | |
| contact affiliation | Dali University |
| contact email | liii_cc@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
