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PXD069632
PXD069632 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mitochondrial contact site and cristae organizing system promotes modular assembly of cytochrome c oxidase |
| Description | Mitochondrial cytochrome c oxidase, the complex IV of the respiratory chain, is assembled in a modular fashion from mitochondrial- as well as nuclear-encoded subunits, guided by numerous assembly factors. This intricate process is further complicated by the characteristic architecture of the inner mitochondrial membrane with its functional asymmetry. The mitochondrial contact site and cristae organizing system (MICOS) maintains the stability of crista junctions that connect the cristae, the site of mitochondrial respiration, with the inner boundary membrane where newly imported respiratory subunits first arrive. Here, we report that MICOS facilitates specific assembly steps of complex IV and associates with intermediates of the Cox1 and Cox3 modules. Moreover, MICOS recruits a variety of assembly factors even in the absence of ongoing complex IV biogenesis. Our results establish MICOS as an important agent in efficient respiratory chain assembly that directly supports and coordinates complex IV biogenesis within the complex inner membrane architecture. |
| HostingRepository | jPOST |
| AnnounceDate | 2025-12-11 |
| AnnouncementXML | Submission_2025-12-10_23:54:26.910.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Enzo Scifo |
| SpeciesList | scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932; |
| ModificationList | S-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; N6-acetyl-L-lysine; L-methionine sulfoxide |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-10-19 07:19:45 | ID requested | |
| ⏵ 1 | 2025-12-10 23:54:27 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: mitochondria, respiratory chain, MICOS, protein assembly, MIMAS, cristae |
Contact List
| Heike Rampelt and Thomas Becker | |
|---|---|
| lab head | |
| Enzo Scifo | |
| contact affiliation | DZNE |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST004128/ |
