PXD068995

PXD068995 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	PROTAC Mediated Structure-Function Disruption of CD26 A Therapeutic Strategy for Driver Negative NSCLC
Description	P4-3 is a PROTAC designed to induce degradation of CD26, a transmembrane glycoprotein with dual oncogenic functions overexpressed in NSCLC. Here, we employed label-free quantitative proteomics to characterize its global proteomic impact on H460 cells. Bottom-up proteomics was performed on samples treated with DMSO or P4-3 (24 hours, 6 biological replicates per group) to assess proteome-wide alterations.
HostingRepository	PRIDE
AnnounceDate	2025-10-28
AnnouncementXML	Submission_2025-10-28_02:38:32.207.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bohao Liu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-30 03:35:46	ID requested
⏵ 1	2025-10-28 02:38:32	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: PROTAC

submitter keyword: PROTAC

Contact List

Bohao Liu
contact affiliation	The First Affiliated Hospital of Xi’an Jiaotong University
contact email	lbh1001@stu.xjtu.edu.cn
lab head
Bohao Liu
contact affiliation	The First Affiliated Hospital of Xi’an Jiaotong University
contact email	lbh1001@stu.xjtu.edu.cn
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD068995
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD068995

PRIDE project URI

Repository Record List

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