PXD068911 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Enterohemorrhagic Escherichia coli O157:H7 responds to norepinephrine gradients by tRNA reprogramming and codon-biased translation of virulence genes |
| Description | We grew Escherichia coli O157:H7 strain EDL933 in low glucose DMEM and exposed it to 0 and 50 micromolar norepinephrine. After 5 hr of growth (37C, shaking 180rpm), cells were pelleted. Protein was then extracted and prepared for TMT-tagged proteomics to analyze for differential protein expression. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-17 |
| AnnouncementXML | Submission_2026-04-17_06:50:55.248.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Abigail McShane |
| SpeciesList | scientific name: Escherichia coli; NCBI TaxID: NEWT:562; |
| ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-09-28 14:23:08 | ID requested | |
| ⏵ 1 | 2026-04-17 06:50:55 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: virulence, translational regulation,tRNA, EHEC O157:H7 |
Contact List
| Peter Dedon |
|---|
| contact affiliation | Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 USA Singapore-MIT Alliance for Research and Technology Antimicrobial Resistance Interdisciplinary Research Group, Singapore 138602 |
| contact email | pcdedon@mit.edu |
| lab head | |
| Abigail McShane |
|---|
| contact affiliation | Massachusetts Institute of Technology |
| contact email | aemcshane@outlook.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD068911 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD068911
- Label: PRIDE project
- Name: Enterohemorrhagic Escherichia coli O157:H7 responds to norepinephrine gradients by tRNA reprogramming and codon-biased translation of virulence genes
