PXD068387 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Dysregulation of muscle myosin biochemical states in X-linked myotubular myopathy |
| Description | Pathogenic variants in MTM1 are associated with a severe, congenital muscle disorder called X-linked myotubular myopathy. Here, we aimed to assess the effect of mavacamten (myosin ATPase inhibitor) treatment in a mouse model for X-linked myotubular myopathy (Mtm1-KO) using the global untargeted proteomics approach. We used skeletal muscle tissue from Mtm1-KO mice and from WT mice, both treated and not treated with mavacamten. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-10-31 |
| AnnouncementXML | Submission_2025-10-31_03:17:07.045.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Michael Wierer |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | timsTOF HT |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-09-15 08:31:17 | ID requested | |
| ⏵ 1 | 2025-10-31 03:17:07 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: skeletal muscle |
| myotubular myopathy |
| MTM1 |
| myosin |
Contact List
| Jenni Laitila |
|---|
| contact affiliation | Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark |
| contact email | jenni.laitila@helsinki.fi |
| lab head | |
| Michael Wierer |
|---|
| contact affiliation | Proteomics Research Infrastructure, University of Copenhagen |
| contact email | michael.wierer@sund.ku.dk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD068387
- Label: PRIDE project
- Name: Dysregulation of muscle myosin biochemical states in X-linked myotubular myopathy
