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PXD066247

PXD066247 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHexosamine Biosynthetic Pathway Drives Tumor Immune Evasion via Translational Control of PD-L1 at the Elongation Level
DescriptionThe hexosamine biosynthetic pathway (HBP) serves as a critical metabolic node in cancer cells that provides the basis for protein glycosylation. Herein, we show that HBP flux inhibition by knocking out its rate-limiting enzyme GFAT1 suppressed tumor growth and stimulated cytotoxic CD8+ T lymphocyte infiltration in a colorectal cancer model.
HostingRepositoryiProX
AnnounceDate2025-07-17
AnnouncementXMLSubmission_2025-08-04_20:07:32.711.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBo Liu
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-07-17 01:09:25ID requested
⏵ 12025-08-04 20:07:33announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Immune Evasion
Contact List
Yuanyuan Ruan
contact affiliationFudan University
contact emailyuanyuanruan@fudan.edu.cn
lab head
Bo Liu
contact affiliationFudan University
contact emailliubo@fudan.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI

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