⮝ Full datasets listing
PXD064941
PXD064941 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Plasma Proteomic Biomarkers for Predicting Chemoradiation Response in Locally Advanced Cervical Cancer |
| Description | A significant proportion of patients with locally advanced cervical cancer (LACC) experience treatment failure following concurrent chemoradiation therapy (CRT). Identifying patients unlikely to respond to CRT could inform personalized treatment strategies. In this study, we evaluated plasma proteomic profiles in 39 LACC patients stratified by CRT response: complete response (CR), partial response (PR), and progressive disease (PD). Using nano-liquid chromatography tandem mass spectrometry with data-independent acquisition (nano-LC MS/MS-DIA), we identified 507 protein groups, of which 407 were consistently detected in more than 50% of samples. Differential expression analysis revealed eight proteins significantly downregulated in non-responders, all of which are involved in inflammatory response pathways. Further subclass analysis demonstrated distinct proteomic dysregulation in PR patients compared to both CR and PD groups, with enrichment of pathways related to complement activation, NF-κB signaling, and lipid metabolism. Targeted validation using parallel reaction monitoring (PRM) confirmed a panel of 11 proteins that robustly distinguished PR from CR, yielding an area under the curve (AUC) of 0.862 (95% CI: 0.793–0.921). Integration with tumor RNA-seq data from The Cancer Genome Atlas (TCGA) revealed coordinated dysregulation in pathways involving HIF-1 signaling, proteoglycan and choline metabolism, PI3K-Akt signaling, and the complement and coagulation cascade. These findings suggest that baseline plasma protein profiles reflect underlying systemic inflammation and metabolic status, offering potential utility in predicting CRT responsiveness in LACC. |
| HostingRepository | jPOST |
| AnnounceDate | 2025-11-03 |
| AnnouncementXML | Submission_2025-11-02_16:01:27.862.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Kittinun Leetanaporn |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-06-12 07:44:16 | ID requested | |
| ⏵ 1 | 2025-11-02 16:01:28 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: locally advanced cervical cancer, plasma, concurrent chemoradiation, proteomics, RNA-seq |
Contact List
| Kittinun Leetanaporn | |
|---|---|
| lab head | |
| Kittinun Leetanaporn | |
| contact affiliation | Prince of Songkla University |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003861/ |
