PXD064795

PXD064795 is an original dataset announced via ProteomeXchange.

Title	Deciphering Mutational Effects on Inducible Nitric Oxide Synthase Conformational Dynamics via Quantitative Cross-Linking Mass Spectrometry and AlphaFold2 Subsampling
Description	In this project, we compare the abundancies of cross-links in wild type and mutant iNOSoxyFMN-CaM complexes at specific interdomain interacting site and map the identified sites onto top AlphaFold 2 models for better understanding of iNOS protein dynamics.
HostingRepository	PRIDE
AnnounceDate	2025-10-30
AnnouncementXML	Submission_2025-10-30_11:11:58.268.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ting Jiang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF fleX MALDI-2

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-09 16:39:50	ID requested
⏵ 1	2025-10-30 11:11:58	announced

Dataset with its publication pending

submitter keyword: NOS, targeted, cross-linking mass spectrometry

Changjian Feng
contact affiliation	University of New Mexico
contact email	cfeng@salud.unm.edu
lab head
Ting Jiang
contact affiliation	UNM
contact email	tjiang@salud.unm.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD064795

PRIDE project URI

• PRIDE
  1. PXD064795
     1. Label: PRIDE project
     2. Name: Deciphering Mutational Effects on Inducible Nitric Oxide Synthase Conformational Dynamics via Quantitative Cross-Linking Mass Spectrometry and AlphaFold2 Subsampling