PXD064724

PXD064724 is an original dataset announced via ProteomeXchange.

Title	Global Matrisome changes in the obese lung are linked to fibroblastic stroma and premature aging
Description	Obesity is associated with an increased risk of lung disorders, yet its effects on lung tissue structure and the microenvironment remain incompletely understood. Using a multiomics strategy combining tissue proteomics, lipidomics, solubility profiling, single-cell transcriptomics, and functional assays, we investigated how obesity affects lung composition and fibroblast behavior. Our data indicate that obesity induces remodeling of the extracellular matrix, including changes in elastic fiber-associated proteins, and is accompanied by reduced levels of protease inhibitors in lung tissue and BALF. Stromal fibroblasts accumulated lipids and exhibited increased contractility, matrisome alterations, and transcriptional hallmarks of aging. Comparison of obese and aging lungs revealed overlapping solubility changes in structural matrix proteins. These findings suggest that obesity may induce premature aging of fibroblasts and consequent remodeling of the lung microenvironment, with potential implications for tissue compliance and repair responses.
HostingRepository	PRIDE
AnnounceDate	2025-08-21
AnnouncementXML	Submission_2025-08-21_05:06:38.760.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Veronika Lukacs-Kornek
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-06 06:52:55	ID requested
⏵ 1	2025-08-21 05:06:39	announced

Dataset with its publication pending

submitter keyword: Mouse, Lung, BALF, Obesity

Veronika Lukacs-Kornek
contact affiliation	Institute of Molecular Medicine and Experimental Immunology, BMZ-II, Building 12, University Hospital Bonn
contact email	vlukacsk@uni-bonn.de
lab head
Veronika Lukacs-Kornek
contact affiliation	University of Bonn
contact email	vlukacsk@uni-bonn.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD064724

PRIDE project URI

• PRIDE
  1. PXD064724
     1. Label: PRIDE project
     2. Name: Global Matrisome changes in the obese lung are linked to fibroblastic stroma and premature aging