PXD063938

PXD063938 is an original dataset announced via ProteomeXchange.

Title	Age-related proteomic profiling of livers from Caspase-2 deficient mice
Description	Caspase-2 function in liver homeostasis is influenced by its important role in mitotic catastrophe to prevent survival and accumulation of aneuploid and polyploid cells. While loss of caspase-2 promotes hepatocyte polyploidy, it is unclear how this influences liver homeostasis with ageing. To address this, this project examined age-related liver proteomic changes, in caspase-2 deficient mice (knockout and catalytic cytsteine mutant- C320S), comparing protein abundance in young (3-month-old) and ageing (12 and 18-month-old) mice. We describe changes in several cell-cycle related and inflammation-related proteins that are associated with early hepatocyte hyperpolyploidy in young caspase-2- deficient mice, as well as increased liver disease in ageing caspase-2 deficient mice. These findings demonstrate that caspase-2 catalytic activity is critical for age-related liver homeostasis by preventing pathogenic hyperpolyploidy, tissue inflammation, tissue damage and survival of pre-neoplastic cells.
HostingRepository	PRIDE
AnnounceDate	2025-11-21
AnnouncementXML	Submission_2025-11-20_17:31:57.900.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Laura Dagley
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-14 17:11:37	ID requested
⏵ 1	2025-11-20 17:31:58	announced

Dataset with its publication pending

submitter keyword: Mus musculus, proteolytic mutation, liver, ageing,Caspase-2, polyploidy

Prof. Sharad Kumar
contact affiliation	Bradley Distinguished Professor Chair of Cancer Biology & Research Professor of Cell Biology Centre for Cancer Biology University of South Australia
contact email	sharad.kumar@unisa.edu.au
lab head
Laura Dagley
contact affiliation	WEHI
contact email	dagley.l@wehi.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD063938

PRIDE project URI

• PRIDE
  1. PXD063938
     1. Label: PRIDE project
     2. Name: Age-related proteomic profiling of livers from Caspase-2 deficient mice