PXD063864

PXD063864 is an original dataset announced via ProteomeXchange.

Title	ZDHHC11-mediated palmitoylation alleviates chondrocyte senescence and serves as a therapeutic target for osteoarthritis [III]
Description	Osteoarthritis (OA) is a chronic, degenerative whole-joint disorder that interferes with quality of life in older individuals. Here, we report a high expression of ZDHHC11 in articular chondrocytes, which is downregulated in the degenerated cartilage of aged mice and OA patients. ZDHHC11 prevents chondrocyte senescence and fosters cartilage anabolism, culminating in an improved OA phenotype. Mice with Zdhhc11 deletion (Zdhhc11fl/fl) exacerbate OA progression in a destabilized medial meniscus (DMM) model. Specifically, we identify ZDHHC11 as a key palmitoyltransferase, the depletion of which leads to GNB2-dependent E3 ubiquitin ligase-mediated proteasomal degradation of APOD.
HostingRepository	PRIDE
AnnounceDate	2025-08-12
AnnouncementXML	Submission_2025-08-12_11:40:50.397.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kefan Wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-12 15:35:39	ID requested
⏵ 1	2025-08-12 11:40:50	announced

Dataset with its publication pending

submitter keyword: osteoarthritis, senescence

Shuying Shen
contact affiliation	Department of Orthopedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou City, China.
contact email	wkf091997@163.com
lab head
Kefan Wang
contact affiliation	Department of Orthopedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou City, 310016, China.
contact email	wkf091997@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD063864

PRIDE project URI

• PRIDE
  1. PXD063864
     1. Label: PRIDE project
     2. Name: ZDHHC11-mediated palmitoylation alleviates chondrocyte senescence and serves as a therapeutic target for osteoarthritis [III]