PXD062399

PXD062399 is an original dataset announced via ProteomeXchange.

Title	Integrating antigen capturing nanoparticles and type 1 conventional dendritic cell therapy for in situ cancer immunization
Description	Eliciting a robust immune response against tumors is often hampered by the inadequate presence of effective antigen presenting cells and their suboptimal ability to present antigens within the immunosuppressive tumor microenvironment. Here, we report a cascade antigen relay strategy integrating antigen capturing nanoparticles (AC-NPs) and migratory type 1 conventional dendritic cells (cDC1s), named Antigen Capturing nanoparticle Transformed Dendritic Cell therapy (ACT-DC), to facilitate in situ immunization. AC-NPs are engineered to capture antigens directly from the tumor and facilitate their delivery to adoptively transferred migratory cDC1s, enhancing antigen presentation to the lymph nodes and reshaping the tumor microenvironment. Our findings suggest that ACT-DC improves in situ antigen collection, triggers a robust systemic immune response without the need for exogenous antigens, and transforms the tumor environment into a more “immune-hot” state. In multiple tumor models including colon cancer, melanoma, and glioma, ACT-DC in combination with immune checkpoint inhibitors eliminates primary tumors in 50-100% of treated mice and effectively rejects two separate tumor rechallenges. Collectively, ACT-DC could provide a broadly effective approach for in situ cancer immunization and tumor microenvironment modulation.
HostingRepository	PRIDE
AnnounceDate	2025-04-03
AnnouncementXML	Submission_2025-04-03_08:30:07.550.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Duong Trinh
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-31 02:10:20	ID requested
⏵ 1	2025-04-03 08:30:07	announced

Dataset with its publication pending

submitter keyword: Antigen, cancer, orbitrap, mouse

Zongmin Zhao
contact affiliation	Dr. Zongmin Zhao. Assistant Professor, Department of Pharmaceutical Sciences, UIC Retzky College of Pharmacy, University of Illinois Chicago
contact email	zhaozm@uic.edu
lab head
Duong Trinh
contact affiliation	UIC
contact email	ngocduong2712@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD062399
     1. Label: PRIDE project
     2. Name: Integrating antigen capturing nanoparticles and type 1 conventional dendritic cell therapy for in situ cancer immunization