PXD062350 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mlycd deficiency in Dahl salt-sensitive rats |
| Description | Mlycd (malonyl-CoA decarboxylase) is a regulator of fatty acid metabolism. Lysine supplementation depletes kidney malonyl-CoA in hypertensive Dahl SS rats. As a key regulatory mechanism, lysine malonylation influences mitochondrial enzymes and fatty acid metabolism, with implications for CKD, hypertension, and other disorders. Yet how the balance between malonylation and acetylation is altered, and how this affects salt-sensitive hypertension, remains unclear. In this study, we examined the proteomic and metabolomic alterations resulting from Mlycd deficiency in Dahl salt-sensitive rats. This dataset contains proteomic profiles of heart, kidney, liver tissues as well as plasma and urine samples obtained from both Mlycd+/+ and Mlycd+/- animals. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-14 |
| AnnouncementXML | Submission_2025-12-14_04:57:12.811.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yifan Tan |
| SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-03-28 07:54:24 | ID requested | |
| ⏵ 1 | 2025-12-14 04:57:13 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Malonyl-CoA, proteomics,Mlycd, metabolomics |
Contact List
| Alexander Staruschenko |
|---|
| contact affiliation | Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA |
| contact email | staruschenko@usf.edu |
| lab head | |
| Yifan Tan |
|---|
| contact affiliation | Aarhus University |
| contact email | tanyifan@biomed.au.dk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD062350 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD062350
- Label: PRIDE project
- Name: Mlycd deficiency in Dahl salt-sensitive rats
