PXD061652

PXD061652 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis for Cisplatin -induced mice spermatogenesis defects
Description	Cisplatin is a crucial chemotherapeutic agent for treating various cancers, but excessive use can cause irreversible damage to the reproductive system. However, the protein expression profile of cisplatin-induced testicular injury remains poorly understood. In this study, we observed that cisplatin treatment resulted in smaller testes, reduced sperm count, and a significant decrease in the number of spermatocytes and spermatids in mice. Further label-free quantitative proteomic analysis revealed that cisplatin reduced the expression of CDK1 in the testes, thereby affecting the number of spermatocytes and spermatids. These findings provide new insights into fertility preservation for cancer patients undergoing chemotherapy.
HostingRepository	PRIDE
AnnounceDate	2025-11-03
AnnouncementXML	Submission_2025-11-03_05:21:34.869.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pengyu Li
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-10 07:44:28	ID requested
⏵ 1	2025-11-03 05:21:35	announced

Dataset with its publication pending

submitter keyword: Human，spermatogenesis, spermatogenic injury, Cisplatin

li pengyu
contact affiliation	Department of Biochemistry and Molecular Biology, State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing 100005, China
contact email	lpy19940126@163.com
lab head
Pengyu Li
contact affiliation	Department of Biochemistry and Molecular Biology, State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, and Peking Union Medical College
contact email	lpy19940126@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD061652

PRIDE project URI

• PRIDE
  1. PXD061652
     1. Label: PRIDE project
     2. Name: Proteomic analysis for Cisplatin -induced mice spermatogenesis defects