PXD061555

PXD061555 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Cell therapy mesenchymal stem cell secretome for cardioprotection
Description	Mesenchymal stem cells (MSCs) offer promising therapeutic effects for cardiac repair, primarily through their secretome, a complex array of bioactive factors with broad, multi-target effects on various cell types and pathological processes. However, current delivery and retention methods lack the ability to provide sustained, stable therapeutic benefits in ischaemic heart disease. This study addresses this limitation by introducing an innovative approach for the prolonged and clinically feasible delivery of MSC-derived secretome for cardioprotection. To evaluate the cardioprotective effects of MSC secretome in a human context, a human-iPSC-derived cardiac organoid model of simulated ischaemia-reperfusion injury was employed. Proteomic analysis of the Cymerus secretome, collected at both pre- and post-implantation, was conducted to investigate the mechanisms underlying its cardiac benefits. Proteomic analysis revealed the secretome of Cymerus comprised 3,851 proteins, with functional enrichment in pathways related to tissue homeostasis, apoptosis regulation, wound healing, and antioxidant defence . Furthermore, the post-implantation MSC secretome demonstrated an upregulation of proteins related to extracellular matrix organization, immune modulation, and tissue remodelling, indicating a temporal and adaptive response of the MSCs to ischaemic conditions.
HostingRepository	MassIVE
AnnounceDate	2025-03-07
AnnouncementXML	Submission_2025-03-07_07:04:58.928.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	David Greening
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Acetyl; Methyl
Instrument	Q Exactive HF-X

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-06 17:33:10	ID requested
⏵ 1	2025-03-07 07:04:59	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: heart, secretome, therapeutic, stem cells, Ischaemia-reperfusion injury, DatasetType:Proteomics

submitter keyword: heart, secretome, therapeutic, stem cells, Ischaemia-reperfusion injury, DatasetType:Proteomics

Contact List

David Greening
contact affiliation	Baker Heart & Diabetes Institute
contact email	david.greening@baker.edu.au
lab head
David Greening
contact affiliation	Baker Heart & Diabetes Institute
contact email	david.greening@baker.edu.au
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v09/MSV000097257/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v09/MSV000097257/