PXD060494

PXD060494 is an original dataset announced via ProteomeXchange.

Title	Urine complement analysis implies complement activation is involved in membranous nephropathy
Description	Total 1,427 differentially expressed proteins were identified between the MN and HC groups. KEGG pathway analysis showed significant enrichment of these DEPs in the complement-activated pathway within the MN group. Additionally, a correlation was found between proteinuria and the levels of 27 urinary complement proteins. Notably, Collectin12 (collec12) and C1s were positively correlated with tubular atrophy/interstitial fibrosis (TIF) and monocyte infiltration. Furthermore, urine CD59 emerged as a predictor of clinical remission. Lower deposition of C5b-9 in renal tissue and higher expression of CD59 were detected in clinical remission group than non-remission group.
HostingRepository	iProX
AnnounceDate	2025-02-01
AnnouncementXML	Submission_2025-04-24_19:05:32.771.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yong Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	deaminated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-04 22:15:35	ID requested
1	2025-02-04 22:17:05	announced
⏵ 2	2025-04-24 19:05:33	announced	2025-04-25: Add Publication.

Xu Y, Li Y, Zhang Y, Li G, Urine complement analysis implies complement activation is involved in membranous nephropathy. Front Med (Lausanne), 12():1515928(2025) [pubmed]

submitter keyword: membranous nephropathy, complement, proteomics, histopathology, clinical remission.

Yong Zhang
contact affiliation	West China Hospital, Sichuan University
contact email	nankai1989@foxmail.com
lab head
Yong Zhang
contact affiliation	West China Hospital, Sichuan University
contact email	nankai1989@foxmail.com
dataset submitter

iProX dataset URI