PXD060311

PXD060311 is an original dataset announced via ProteomeXchange.

Title	A boundary-defining protein facilitates megabase-scale regulatory chromosomal loop formation in Drosophila neurons
Description	Meta-loops are large chromosomal loops that connect specific neuronal genes with non-coding DNA elements, enabling megabase-range regulation of gene transcription in fly neurons. To reveal how highly specific meta-loop interactions form, we developed an unbiased approach to identify proteins from Drosophila adult head extracts that associate with four meta-loop anchors and a control. This approach revealed both known and new factors involved in meta-loop formation, including Lola-I which we functionally validate as a meta-loop anchor binding protein required a small subset of meta-loops.
HostingRepository	PRIDE
AnnounceDate	2025-04-11
AnnouncementXML	Submission_2025-04-11_05:40:25.455.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Maria Cristina Gambetta
SpeciesList	scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-29 02:24:35	ID requested
⏵ 1	2025-04-11 05:40:25	announced

Dataset with its publication pending

submitter keyword: meta-loop, neuron, 3D genome organization, Cp190,Drosophila, transcription factor, Lola

Maria Cristina
contact affiliation	Center for Integrative Genomics (CIG) University of Lausanne (UNIL) Quartier Sorge, Genopode room 3030 CH-1015 Lausanne Switzerland
contact email	mariacristina.gambetta@unil.ch
lab head
Maria Cristina Gambetta
contact affiliation	Center for Integrative Genomics University of Lausanne
contact email	mariacristina.gambetta@unil.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD060311

PRIDE project URI

• PRIDE
  1. PXD060311
     1. Label: PRIDE project
     2. Name: A boundary-defining protein facilitates megabase-scale regulatory chromosomal loop formation in Drosophila neurons