PXD058556

PXD058556 is an original dataset announced via ProteomeXchange.

Title	The maternal vitamin D level regulates the metabolic rearrangement of offspring-CD4+ T cells in response to intestinal inflammation
Description	In this study, we aim to demonstrate the immunomodulatory mechanisms of maternal VitD on the offspring. We found that high maternal VitD levels rescue the abnormal immune phenotype caused by maternal immune activation (MIA), and inhibit the transformation of CD4+ T cells into a pro-inflammatory phenotype through a maternal VitD concentration-dependent regulation of metabolism and epigenetic reprogramming. Furthermore, we identified critical windows for maternal VitD regulation of offspring immunity, as well as the long-term impacts of MIA.
HostingRepository	iProX
AnnounceDate	2024-12-04
AnnouncementXML	Submission_2025-03-31_19:49:43.010.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Binjun Zhu
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-04 00:23:25	ID requested
⏵ 1	2025-03-31 19:49:43	announced

Dataset with its publication pending

submitter keyword: pregnancy, vitamin D, maternal immune activation, interleukin-17A, interferon-gamma, inflammatory bowel diseases, oxidative phosphorylation

Jiang Xie
contact affiliation	The Third People's Hospital of Chengdu
contact email	xiejiang@swjtu.edu.cn
lab head
Binjun Zhu
contact affiliation	North Sichuan Medical College
contact email	438073257@qq.com
dataset submitter

iProX dataset URI