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PXD058454

PXD058454 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic analysis of Escherichia coli Nissle 1917 derived outer membrane vesicles (EcN-derived OMVs) and the EcN-derived OMVs of three specific sizes
DescriptionProbiotic bacterium Escherichia coli Nissle 1917 (EcN) is a Gram-negative probiotic bacterium found in the human intestine. Related researches have shown that EcN has good effects in regulating host immune function and treating intestinal diseases. Compared with EcN probiotics themselves, EcN-derived outer membrane vesicles (OMVs) are more likely to spread, cross the mucus layer, and migrate directly to the intestinal submucosa tissue to interact with cells of the host immune system. EcN-derived OMVs play an important role in intestinal immune regulation. However, there are relatively few studies on the regulation of intestinal immunity by EcN-derived OMVs of different sizes. In this project, we first isolated EcN-derived OMVs and then conducted proteomic analyses on the isolated EcN-derived OMVs. Second, we used the filtration method to obtain EcN-derived OMVs of three specific sizes: < 50 nm, 50–100 nm, and 100–300 nm. We then conducted proteomic analyses on EcN-derived OMVs of three specific sizes.
HostingRepositoryiProX
AnnounceDate2024-11-30
AnnouncementXMLSubmission_2024-12-01_23:19:05.804.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterNing Li
SpeciesList scientific name: Escherichia coli Nissle 1917; NCBI TaxID: 316435;
ModificationListacetylated residue
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-12-01 23:18:43ID requested
12024-12-01 23:19:06announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Escherichia coli Nissle 1917, Outer membrane vesicles, Heterogeneity, Different sizes
Contact List
Keyu Deng
contact affiliationNanchang University
contact emaildky@ncu.edu.cn
lab head
Ning Li
contact affiliationNanchang University
contact email464774051@qq.com
dataset submitter
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