PXD057949

PXD057949 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	MEF2A, MEF2C, and MEF2D Interactomes in Mouse MA-10 Leydig Cells
Description	In steroidogenic Leydig cells, MEF2A, MEF2C, and MEF2D are key regulators of genes involved in steroid hormone synthesis, reproductive function, and oxidative stress defense. Here we used TurboID proximity-mediated biotinylation to map the protein-protein interaction networks of MEF2A, MEF2C, and MEF2D in mouse MA-10 Leydig cells. Interactions were captured under both basal (unstimulated) and forskolin-stimulated conditions to examine differences in the MEF2 interactomes in relation to steroidogenesis. This dataset provides insights into MEF2-related signalling pathways and the functional landscape of MEF2 transcription factors in Leydig cells.
HostingRepository	MassIVE
AnnounceDate	2025-04-22
AnnouncementXML	Submission_2025-04-22_06:02:52.936.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Jacques J. Tremblay
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-15 12:57:39	ID requested
⏵ 1	2025-04-22 06:02:53	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: protein-protein interaction, transcription factors, steroidogenesis, TurboID, proximity labelling, Leydig cells, DatasetType:Proteomics

submitter keyword: protein-protein interaction, transcription factors, steroidogenesis, TurboID, proximity labelling, Leydig cells, DatasetType:Proteomics

Contact List

Jacques J Tremblay
contact affiliation	Universite Laval
contact email	jacques-j.tremblay@crchudequebec.ulaval.ca
lab head
Jacques J. Tremblay
contact affiliation	Universite Laval
contact email	Jacques-J.Tremblay@crchudequebec.ulaval.ca
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v07/MSV000096432/