PXD057820

PXD057820 is an original dataset announced via ProteomeXchange.

Title	Proteomic and Acetylation Profiling of Stemness Induced by Soft Matrix in Breast Cancer Repopulating Cells
Description	Compared to regular tumor cells, cancer stem cells exhibit dangerous characteristics, including high proliferation, high metastatic potential, and significantly increased in vivo tumorigenicity. Although some studies have emphasized the impact of the microenvironment on cell stemness, they have largely overlooked the mechanical forces derived from the stiffness of the surrounding extracellular matrix. Our previous research demonstrated that a 90 Pa soft fibrin matrix in 3D culture can induce cells to become Cancer Repopulating Cells with high stemness. Acetylation modification significantly influences the metabolism, epigenetics, proliferation, and migration of tumor cells. In this study, we performed a comprehensive analysis of the proteome and acetyl-proteome of breast cancer cells under 2D plate and 3D matrix conditions with varying stiffness.
HostingRepository	iProX
AnnounceDate	2025-02-08
AnnouncementXML	Submission_2025-02-08_00:36:20.853.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rong Han
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	acetylated residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-12 20:07:23	ID requested
⏵ 1	2025-02-08 00:36:21	announced

Dataset with its publication pending

submitter keyword: Cancer Repopulating Cells, Matrix Stiffness

Juntao Yang
contact affiliation	Peking Union Medical College
contact email	superyjt79@163.com
lab head
Rong Han
contact affiliation	Peking Union Medical College
contact email	905556219@qq.com
dataset submitter

iProX dataset URI