⮝ Full datasets listing
PXD056964
PXD056964 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | RNA Structure Coordinates Translation Across the Meiotic Program |
| Description | Meiosis is a fundamental eukaryotic process characterized by intricate chromosomal behaviors that severely limit transcriptional activities. A pivotal question in this context is how mRNAs, transcribed in preparation for meiosis, are selectively translated at specific stages to ensure an accurate meiotic program. We measured mRNA abundance, mRNA structure, and protein abundance across yeast sporulation to reveal the role of mRNA structure in translation regulation. We found the structures of transcripts upregulated during meiosis were flexible overall, which enhanced translation efficiency, whereas complex structures delayed translation timing, particularly in abundant mRNAs. We observed a high-low-high oscillation in global RNA helicase levels during meiosis, which dynamically allocated ribosome resources as a function of mRNA structural complexity, thus impacting translation timing. Altering Ded1p helicase levels interfered with meiotic proteostasis, hindering meiosis progression. This work reveals how transcript-specific degrees in RNA folding, across thousands of genes, coordinate stage-specific translation, highlighting a pivotal post-transcriptional regulatory layer when transcription is compromised by chromosome condensation. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-01-15 |
| AnnouncementXML | Submission_2026-01-15_15:14:28.266.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hao Wu |
| SpeciesList | scientific name: Saccharomyces cerevisiae; common name: baker's yeast; NCBI TaxID: 4932; |
| ModificationList | unknown modification |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-10-19 00:58:52 | ID requested | |
| ⏵ 1 | 2026-01-15 15:14:28 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: yeast meiosis, protein dynamics, Ded1 overexpression, DatasetType:Proteomics |
Contact List
| Yun Bai | |
|---|---|
| contact affiliation | ShanghaiTech University |
| contact email | ybai@shanghaitech.edu.cn |
| lab head | |
| Hao Wu | |
| contact affiliation | ShanghaiTech University |
| contact email | wuhao@alumni.shanghaitech.edu.cn |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v08/MSV000096134/ |
