PXD056753
PXD056753 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Multi-organ Proteomic and Phosphoproteomic Profiles of Mpox Virus Infection in SIVmac239-infected Rhesus Macaques |
| Description | Macaque study was conducted in an ABSL-3 facility, adhering to protocols approved by the Institutional Animal Care and Use Committee (IACUC) under the guidelines of the Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (Approval Number XJ23004). All animals were single-housed and cared for in a facility fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care. Six rhesus macaques (3 males and 3 females), aged 6–8 years, were inoculated with SIVmac239 at a dose of 100 TCID50 via the intravenous (I.V.) route. On day 115 post-challenge, these 6 rhesus macaques, along with 6 new rhesus macaques (3 males and 3 females, aged 6–8 years), were challenged with 1×107 TCID50 of MPXV through the I.V. route. Half of the rhesus macaques were necropsied on day 10 post-MPXV infection for tissue viral load assessment, histopathology, and proteomic and phosphoproteomic analyses. |
| HostingRepository | iProX |
| AnnounceDate | 2024-10-12 |
| AnnouncementXML | Submission_2025-07-22_20:57:53.688.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jiangfeng Liu |
| SpeciesList | scientific name: Macaca mulatta; NCBI TaxID: 9544; |
| ModificationList | phosphorylated residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-10-12 01:01:47 | ID requested | |
| ⏵ 1 | 2025-07-22 20:57:54 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: monkeypox virus (MPXV), Simian immunodeficiency virus (SIV), rhesus macaques, proteome, phosphoproteome, skin lesion, multiple organs |
Contact List
| Juntao Yang | |
|---|---|
| contact affiliation | Peking Union Medical College |
| contact email | yangjt@pumc.edu.cn |
| lab head | |
| Jiangfeng Liu | |
| contact affiliation | Peking Union Medical College |
| contact email | liujiangf@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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