PXD056729
PXD056729 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Lysosomal protein atlas of brain cell types identifies SLC45A1-associated disease as a lysosomal disorder |
| Description | We identify dozens of novel lysosomal proteins across brain cells, including those linked to disease. Notably, we found that SLC45A1, mutations in which cause a monogenic neurological disease, is a neuron-specific lysosomal protein. Here, we characterize the change in proteomic composition of the lysosome upon SLC45A1 KO, under fed and starved (serum deprived) conditions, as well as global whole cell proteomic changes. Note: Raw file names do not match real conditions. For proper condition assignment, please check the conditions table. |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-07-19 |
| AnnouncementXML | Submission_2025-07-21_11:29:12.405.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Leibniz FLI Proteomics |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Oxidation; Acetyl; Carbamidomethyl |
| Instrument | Orbitrap Exploris 480; nanoACQUITY UPLC System with 1D Technology |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-10-11 07:14:23 | ID requested | |
| ⏵ 1 | 2025-07-21 11:29:12 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: LysoIP, DatasetType:Proteomics |
Contact List
| Alessandro Ori | |
|---|---|
| contact affiliation | Leibniz Institute on Aging Fritz Lipmann Institute (FLI) |
| contact email | alessandro.ori@leibniz-fli.de |
| lab head | |
| Leibniz FLI Proteomics | |
| contact affiliation | Leibniz FLI |
| contact email | proteomics@leibniz-fli.de |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v08/MSV000096063/ |
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