PXD056657

PXD056657 is an original dataset announced via ProteomeXchange.

Title	Lysosomal protein atlas of brain cell types identifies SLC45A1-associated disease as a lysosomal disorder
Description	We identify dozens of novel lysosomal proteins across brain cells, including those linked to disease. Notably, we found that SLC45A1, mutations in which cause a monogenic neurological disease, is a neuron-specific lysosomal protein. Here, we identify potential interaction partners of SLC45A1, but also TMEM192, a well-known lysosomal transmembrane protein.
HostingRepository	MassIVE
AnnounceDate	2026-01-09
AnnouncementXML	Submission_2026-01-09_23:41:35.608.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Leibniz FLI Proteomics
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Oxidation; Acetyl; Carbamidomethyl; Biotin
Instrument	Orbitrap Exploris 480; nanoACQUITY UPLC System with 1D Technology

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-09 08:57:09	ID requested
⏵ 1	2026-01-09 23:41:36	announced

no publication

submitter keyword: BioID

Alessandro Ori
contact affiliation	Leibniz Institute on Aging Fritz Lipmann Institute (FLI)
contact email	alessandro.ori@leibniz-fli.de
lab head
Leibniz FLI Proteomics
contact affiliation	Leibniz FLI
contact email	proteomics@leibniz-fli.de
dataset submitter

MassIVE dataset URI

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v08/MSV000096053/