PXD056639
PXD056639 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Chemoproteomic profiling reveals the mechanism of bile acid tolerance in pathogens |
Description | As amphipathic molecules, BAs have strong antibacterial effects, preventing overgrowth of the gut microbiota and defending the invasion of pathogens. However, some disease-causing pathogens can survive from the BA stress and knowledge is limited about how they develop BA tolerance. In the current study, we applied a quantitative chemoproteomic strategy to profile BA-interacting proteins in bacteria, aiming to discover the sensing pathway of BAs. By using the clickable and photo-affinity analogue BA probes with quantitative mass spectrometry, we identified 588 CA-interacting proteins and 435 DCA-interacting proteins. |
HostingRepository | iProX |
AnnounceDate | 2024-10-09 |
AnnouncementXML | Submission_2024-10-09_00:30:43.517.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Biwei Liu |
SpeciesList | scientific name: Escherichia coli; NCBI TaxID: 562; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-10-09 00:30:28 | ID requested | |
⏵ 1 | 2024-10-09 00:30:43 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Bile acids |
Chemoproteomics |
Contact List
Chu Wang | |
---|---|
contact affiliation | Peking University |
contact email | chuwang@pku.edu.cn |
lab head | |
Biwei Liu | |
contact affiliation | Peking University |
contact email | liubiwei1994@pku.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |