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PXD056639

PXD056639 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleChemoproteomic profiling reveals the mechanism of bile acid tolerance in pathogens
DescriptionAs amphipathic molecules, BAs have strong antibacterial effects, preventing overgrowth of the gut microbiota and defending the invasion of pathogens. However, some disease-causing pathogens can survive from the BA stress and knowledge is limited about how they develop BA tolerance. In the current study, we applied a quantitative chemoproteomic strategy to profile BA-interacting proteins in bacteria, aiming to discover the sensing pathway of BAs. By using the clickable and photo-affinity analogue BA probes with quantitative mass spectrometry, we identified 588 CA-interacting proteins and 435 DCA-interacting proteins.
HostingRepositoryiProX
AnnounceDate2024-10-09
AnnouncementXMLSubmission_2024-10-09_00:30:43.517.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBiwei Liu
SpeciesList scientific name: Escherichia coli; NCBI TaxID: 562;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-10-09 00:30:28ID requested
12024-10-09 00:30:43announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Bile acids
Chemoproteomics
Contact List
Chu Wang
contact affiliationPeking University
contact emailchuwang@pku.edu.cn
lab head
Biwei Liu
contact affiliationPeking University
contact emailliubiwei1994@pku.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI