PXD056543

PXD056543 is an original dataset announced via ProteomeXchange.

Title	PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins
Description	Protein Serine Kinase H1 (PSKH1) was recently identified as a crucial factor in kidney development and is overexpressed in prostate, lung and kidney cancers. However, little is known about PSKH1’s regulation, leading to its classification as a “dark” kinase. Here, we used biochemistry and mass spectrometry to define PSKH1’s consensus substrate motif, protein interactors, and how interactors, including Ca2+ sensor proteins, promote or suppress activity.
HostingRepository	PRIDE
AnnounceDate	2025-01-26
AnnouncementXML	Submission_2025-01-26_13:42:31.725.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Laura Dagley
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-07 05:14:31	ID requested
⏵ 1	2025-01-26 13:42:32	announced

Dataset with its publication pending

submitter keyword: Protein kinase

allosteric regulation

Calumenin

ERC-55

Cab-45

James M. Murphy
contact affiliation	Head, Inflammation Division Professor and NHMRC Leadership Fellow Walter and Eliza Hall Institute of Medical Research 1G Royal Parade Parkville, VIC 3052, Australia
contact email	jamesm@wehi.edu.au
lab head
Laura Dagley
contact affiliation	WEHI
contact email	dagley.l@wehi.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD056543

PRIDE project URI

• PRIDE
  1. PXD056543
     1. Label: PRIDE project
     2. Name: PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins