PXD056487
PXD056487 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Human skeletal muscle bioenergetic pathways are altered in Alzheimers disease |
Description | Skeletal muscle involvement in Alzheimers disease (AD) is supported by reduced lean mass, motor function and mitochondrial respiration in early disease. However, no one has comprehensively assessed molecular alterations in muscle that could underly these findings. We used two human muscle types, quadriceps (n=81) and temporalis (n=66), to compare the skeletal muscle proteome between individuals with and without AD (AD: n= 54 temporalis, 44 quadriceps; controls: n=27 temporalis, 22 quadriceps). We compared the effects of diagnosis between muscle types and in APOE4 carriers versus APOE4 non-carriers. Mitochondrial pathways in skeletal muscle are downregulated in AD. These effects are greatest in the temporalis compared to the quadriceps and in APOE4 carriers compared to APOE4 non-carriers. |
HostingRepository | MassIVE |
AnnounceDate | 2025-05-15 |
AnnouncementXML | Submission_2025-05-15_09:17:08.027.xml |
DigitalObjectIdentifier | |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Michaella Rekowski |
SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
ModificationList | Oxidation; Carbamidomethyl |
Instrument | timsTOF HT |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-10-03 09:31:45 | ID requested | |
⏵ 1 | 2025-05-15 09:17:08 | announced |
Publication List
no publication |
Keyword List
submitter keyword: Alzheimers disease, skeletal muscle, DIA proteomics |
Contact List
Jill K Morris | |
---|---|
contact affiliation | University of Kansas Medical Center |
contact email | jmorris2@kumc.edu |
lab head | |
Michaella Rekowski | |
contact affiliation | University of Kansas Medical Center |
contact email | mrekowski@kumc.edu |
dataset submitter |
Full Dataset Link List
MassIVE dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v08/MSV000096022/ |