PXD056487

PXD056487 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Human skeletal muscle bioenergetic pathways are altered in Alzheimers disease
Description	Skeletal muscle involvement in Alzheimers disease (AD) is supported by reduced lean mass, motor function and mitochondrial respiration in early disease. However, no one has comprehensively assessed molecular alterations in muscle that could underly these findings. We used two human muscle types, quadriceps (n=81) and temporalis (n=66), to compare the skeletal muscle proteome between individuals with and without AD (AD: n= 54 temporalis, 44 quadriceps; controls: n=27 temporalis, 22 quadriceps). We compared the effects of diagnosis between muscle types and in APOE4 carriers versus APOE4 non-carriers. Mitochondrial pathways in skeletal muscle are downregulated in AD. These effects are greatest in the temporalis compared to the quadriceps and in APOE4 carriers compared to APOE4 non-carriers.
HostingRepository	MassIVE
AnnounceDate	2025-05-15
AnnouncementXML	Submission_2025-05-15_09:17:08.027.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michaella Rekowski
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Oxidation; Carbamidomethyl
Instrument	timsTOF HT

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-03 09:31:45	ID requested
⏵ 1	2025-05-15 09:17:08	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: Alzheimers disease, skeletal muscle, DIA proteomics

submitter keyword: Alzheimers disease, skeletal muscle, DIA proteomics

Contact List

Jill K Morris
contact affiliation	University of Kansas Medical Center
contact email	jmorris2@kumc.edu
lab head
Michaella Rekowski
contact affiliation	University of Kansas Medical Center
contact email	mrekowski@kumc.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v08/MSV000096022/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v08/MSV000096022/