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PXD056487

PXD056487 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHuman skeletal muscle bioenergetic pathways are altered in Alzheimers disease
DescriptionSkeletal muscle involvement in Alzheimers disease (AD) is supported by reduced lean mass, motor function and mitochondrial respiration in early disease. However, no one has comprehensively assessed molecular alterations in muscle that could underly these findings. We used two human muscle types, quadriceps (n=81) and temporalis (n=66), to compare the skeletal muscle proteome between individuals with and without AD (AD: n= 54 temporalis, 44 quadriceps; controls: n=27 temporalis, 22 quadriceps). We compared the effects of diagnosis between muscle types and in APOE4 carriers versus APOE4 non-carriers. Mitochondrial pathways in skeletal muscle are downregulated in AD. These effects are greatest in the temporalis compared to the quadriceps and in APOE4 carriers compared to APOE4 non-carriers.
HostingRepositoryMassIVE
AnnounceDate2025-05-15
AnnouncementXMLSubmission_2025-05-15_09:17:08.027.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMichaella Rekowski
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListOxidation; Carbamidomethyl
InstrumenttimsTOF HT
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-10-03 09:31:45ID requested
12025-05-15 09:17:08announced
Publication List
no publication
Keyword List
submitter keyword: Alzheimers disease, skeletal muscle, DIA proteomics
Contact List
Jill K Morris
contact affiliationUniversity of Kansas Medical Center
contact emailjmorris2@kumc.edu
lab head
Michaella Rekowski
contact affiliationUniversity of Kansas Medical Center
contact emailmrekowski@kumc.edu
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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