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PXD056412

PXD056412 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAdipose tissue protein kinase D (PKD): regulation of signalling networks and its effect on metabolism
DescriptionThe protein kinase D (PKD) family of three highly homologous isoforms (PKD1, PKD2, and PKD3) are implicated as nutrient sensing signalling kinases that regulate the response of adipose and other tissues to the nutrient environment. However, the physiological role of adipose tissue PKD and the cellular signalling targets downstream of adipose tissue PKD are not well characterised. Here we employed phosphoproteomics to elucidate signalling events downstream of PKD activation in differentiated 3T3-L1 adipocytes using a triple isoform siRNA knockdown model. This identified PKD-regulated pathways including insulin and cAMP signalling, which control metabolic responses in adipose tissue.
HostingRepositoryPRIDE
AnnounceDate2025-05-27
AnnouncementXMLSubmission_2025-05-26_18:20:21.255.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSean Humphrey
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListphosphorylated residue
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-09-30 22:26:55ID requested
12025-05-26 18:20:21announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Human, adipose tissue, phosphoproteomics
Contact List
Sean Humphrey
contact affiliationStem Cell Medicine, Functional Phosphoproteomics Lab, Murdoch Children's Research Institute, Australia
contact emailsean.humphrey@mcri.edu.au
lab head
Sean Humphrey
contact affiliationMurdoch Children's Research Institute
contact emailsean.j.humphrey@gmail.com
dataset submitter
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Dataset FTP location
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