PXD056410

PXD056410 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Longitudinal analysis of B- and T-cell responses to SARS-CoV-2 recombinant S-protein vaccine S-268019-b in phase 1/2 priming and booster study
Description	The durability of vaccine-induced immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for preventing infection, especially severe disease. This follow-up report after homologous booster vaccination in a phase 1/2 study of S-268019-b (a recombinant spike protein vaccine) confirms the long-term safety, tolerability, and immunogenicity. Booster vaccination of S-268019-b resulted in an enhancement of serum neutralizing antibody (NAb) titers and a broad range of viral neutralization. Single-cell immune profiling revealed persistent and mature antigen-specific memory B cells and T follicular helper cells, with increased B-cell receptor diversity. The expansion of B- and T-cell repertoires and cross-reactive NAbs targeting conserved epitopes within the receptor-binding domain following a booster, accounted for the broad-spectrum neutralizing activity. These finding highlights the potential of S-268019-b to provide broad and robust protection against a range of SARS-CoV-2 variants, addressing a critical challenge in the ongoing fight against coronavirus disease 2019 (COVID-19).
HostingRepository	jPOST
AnnounceDate	2025-03-05
AnnouncementXML	Submission_2025-03-04_22:10:07.549.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Masahiro Takayama
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	unknown modification; unknown modification
Instrument	instrument

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-30 19:34:00	ID requested
⏵ 1	2025-03-04 22:10:07	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: SARS-CoV-2, S268019b, COVID-19 vaccine, Immunogenicity, Neutralizing antibodies, Single-cell analysis, Repertoire analysis, Humoral immunity, Cellular immunity, Vaccine safety

submitter keyword: SARS-CoV-2, S268019b, COVID-19 vaccine, Immunogenicity, Neutralizing antibodies, Single-cell analysis, Repertoire analysis, Humoral immunity, Cellular immunity, Vaccine safety

Contact List

Shinya Omoto
lab head
Masahiro Takayama
contact affiliation	Shionogi & Co., Ltd.
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003388/